seoul @[email protected]

今天错把半包韩国烧烤腌料当成酸辣汤粉包放锅里了，结果倒是做出了一碗味道还可以的酸辣汤面，无意间混合两种粉包的意外结果。

如果从明朝或者乾隆年间开始海上贸易，那么有一个问题似乎避不开，那就是当时的统治者是否会加入奴隶贸易去买卖人口？因为没有什么资料显示古代中国对奴隶买卖有特别的反对条款。
A question tribute to Martin Luther King Jr. Day.

第十版把英文去掉了，改叫奈玛特韦片了。。。

中文的第九版诊疗手册里是写的是paxlovid 等于300mgPF-07321332+100mg利托那韦Ritonavir一起服用，我本来还在想这不是音译啊，原来paxlovid就没有翻译过来。

To make their antiviral candidate Paxlovid, the team combined PF-07321332 with the HIV antiviral ritonavir. Owen says this approach was one the researchers thought they might have to take from the beginning of the project. Ritonavir has no activity against SARS-CoV-2 but does bind to metabolizing enzymes, thereby preventing PF-07321332 from being broken down before it has done its job mucking up the virus’s main protease.

But with its peptide-like structure, PF-00835231 is rich in hydrogen bond donors. It has five of them, and they give the molecule a polar surface area that traps it in the gut if swallowed. This means the molecule must be administered intravenously—something that can typically only be done in a hospital setting. Pfizer scientists wanted an antiviral pill that people could take at the first signs of infection, long before they had to go to the hospital.

In 2003, researchers at the company developed an antiviral, known as PF-00835231, that could block the main protease of a coronavirus that emerged in 2002 and causes severe acute respiratory syndrome (SARS). But by the time they were ready to test it in patients, the SARS outbreak had been contained. PF-00835231 is structurally similar to a peptide that binds within SARS’s main protease. That binding site in SARS is identical to the one in SARS-CoV-2, so Pfizer researchers thought the molecule could work against the new virus. Tests showed they were right.

How Pfizer scientists transformed an old drug lead into a COVID-19 antiviral
Behind the scenes of the medicinal chemistry campaign that led to the pill Paxlovid

@ziwendong 没失去嗅觉味觉？

Pollinators are responsible for one of every three bites of food we take, according to the agency, but their numbers have been declining for many years.

U.S. beekeepers lost nearly 40% of their honeybee colonies in winter 2019, according to a survey by the Bee Informed Partnership.

Bee decline has many causes, including decreasing crop diversity, poor beekeeping practices and loss of habitat. Pesticides weaken bees' immune systems and can kill them. Varroa mites latch onto honeybees and suck their "fat body" tissue, stunting and weakening them and potentially causing entire colonies to collapse.